If you are using a unix host, try the following from /opt/splunk/bin:
splunk _internal call /services/apps/local/dbx/_reload -auth admin:$ADMINPWD
It is important to note that although some components of the app can be reloaded in this manner (databases.conf for password encryption), other components (like the java bridge server) will require a restart as per the output message from the command above:
Restart required by:
ui-prefs, authorize, java, web, ui-prefs
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