Does Splunk monitor and alert on changes to servers (and potentially desktops) configurations?
What kind of changes are you looking to alert on? If it logs an event you can generate an alert with a scheduled search in Splunk to monitor for those changes. It's mostly finding what indicates a config change, ingesting that into Splunk, and configuring a search to alert based on your alert thresholds. Whether that be Windows registry changes, Wineventlog events, or other application events.